I have the X-fi Titanium PCIE card with those speakers and everything is great. Upgraded from the audigy2zs as well. I know there are build-quality type things that are better with azunetech and asus, but unless you are an audiophile it's not worth the higher price, imo. It is kinda funny, I swore I'd never get another creative labs product because of probs with that soundcard and its support but to tell the truth I've been pretty happy with the x-fi.
I guess some questions in your situation are: Are you running vista/windows 7 or planning to? If so the support is seriously lacking with the audigys, whereas I've been very content with the drivers and apps for my x-fi in vista. To go along with that: are you looking for the very best sound in games? If so, the x-fi includes alchemy which maps all the legacy EAX soundmapping to the newer openAL standard. So that's a plus in that case.
There is also better support for using optical-out with the x-fi(and the others I guess) but as I just use the direct connections, I can't really say much on that point.
All in all, its just what you want and whatever you will be happy with in your setup.
Core i7 920 @ 3.8Ghz | 6GB OCZ DDR3 8-8-8-24 @ 1600mhz | eVga x58 Mobo | 2 x eVga GTX 460 SLI | Intel X25-M + 3x Seagate + WD Black = 2.75TB | X-Fi Titanium | PCP&C Silencer 750 | G15 KB | G5 Mouse | G35 Headset | Z-5500 Digital | Samsung T260HD
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