I´ve been using Vista since i got my new PC, that was in October/november. I actually haven´t noticed any major problems, really. Everything ive tried has worked just as it did with XP. Warez/games/apps, (daemon tools too), most of my drivers (only had some problems with my wireless adapter, but thats Netgears fault for not giving a fuck).
Watercooled 5950X | AORUS Master X570 | Asus RTX 3090 TUF Gaming OC | 64Gb RAM | 1Tb 970 Evo Plus + 2Tb 660p | etc etc