The 3D-Spheric-Mouse isn't really designed to replace a conventional mouse, but rather to complement one: you can use a normal mouse with one hand and a 3D mouse with the other, replacing any number of awkward keyboard shortcuts with this more intuitive interface. It'll be most useful for people who spend a lot of time in CAD environments or doing 3D modeling, but it's good for way more than that.
3d design, i dunno I find my pen and tablet the best thing for 3d modeling etc. And its also kick ass to use in certain games that use UI's which are more than a main menu etc for a game.. Eve online is one game that a pen and tablet works really well in.
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